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  2. Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers and signature.

    Authors: Cui Zhao, Jian Liu, Haomiao Zhou, Xin Qian, Hui Sun, Xuewen Chen, Miaosen Zheng, Tingting Bian, Lei Liu, Yifei Liu and Jianguo Zhang

    Citation: Cancer Cell International 2021 21:228

    Content type: Primary research

    Published on:

  3. The purpose of this study is to explore the effect of miRNA-539 on osteosarcoma (OS) and the underlying mechanism, so as to find a new method for early diagnosis and treatment of osteosarcoma.

    Authors: Huowen Liu, Min Yang, Yufeng Zhang, Zhiqiang Yang, Zhe Chen, Yuanlong Xie, Binglong Peng and Lin Cai

    Citation: Cancer Cell International 2021 21:227

    Content type: Primary research

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  4. Urothelial carcinoma (UC) is the second most common malignancy of the urinary system with high rate of recurrence, UC patients therefore needed to be treated with surgery followed by chemotherapy. Development ...

    Authors: Yeong-Chin Jou, Guan-Ling Lin, Hon-Yi Lin, Wan-Hong Huang, Yu-Ming Chuang, Ru-Inn Lin, Pie-Che Chen, Shu-Fen Wu, Cheng-Huang Shen and Michael W. Y. Chan

    Citation: Cancer Cell International 2021 21:226

    Content type: Primary research

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  5. Intrahepatic cholangiocarcinoma (iCCA) is the second most common malignant hepatic tumor and has a high postoperative recurrence rate and a poor prognosis. The key roles of most tumor recurrence-associated mol...

    Authors: Fengwei Li, Qinjunjie Chen, Yang Yang, Meihui Li, Lei Zhang, Zhenlin Yan, Junjie Zhang and Kui Wang

    Citation: Cancer Cell International 2021 21:225

    Content type: Primary research

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  6. We aimed to understand the clinical characteristics and better predict the prognosis of patients with mucosal melanoma of the head and neck (MMHN) using a nomogram.

    Authors: Qing-Qing Xu, Qing-Jie Li, Liu Chen, Xin-Yi Su, Jing-Xia Song, Juan Du, Lei Chen and Li-Xia Lu

    Citation: Cancer Cell International 2021 21:224

    Content type: Primary research

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  8. Clear cell renal cell carcinoma (ccRCC) has been the commonest renal cell carcinoma (RCC). Although the disease classification, diagnosis and targeted therapy of RCC has been increasingly evolving attributing ...

    Authors: Xiaoqin Zhang, Ziyue Wang, Zixin Zeng, Ningning Shen, Bin Wang, Yaping Zhang, Honghong Shen, Wei Lu, Rong Wei, Wenxia Ma and Chen Wang

    Citation: Cancer Cell International 2021 21:222

    Content type: Primary research

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  9. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules containing only 20–22 nucleotides. MiRNAs play a role in gene silencing and translation suppression by targeting and binding to mRNA. Proper cont...

    Authors: Yufei Tang, Shaoqi Zong, Hailun Zeng, Xiaofeng Ruan, Liting Yao, Susu Han and Fenggang Hou

    Citation: Cancer Cell International 2021 21:221

    Content type: Review

    Published on:

  10. Serine hydroxymethyltransferase 2 (SHMT2) is a vital metabolic enzyme in one carbon metabolism catalyzing the conversion of serine to glycine, which has been reported to play a crucial role in the progression ...

    Authors: Yan Liao, Fang Wang, Yadong Zhang, Hongshi Cai, Fan Song and Jinsong Hou

    Citation: Cancer Cell International 2021 21:220

    Content type: Primary research

    Published on:

  11. Given that dysregulated metabolism has been recently identified as a hallmark of cancer biology, this study aims to establish and validate a prognostic signature of lung adenocarcinoma (LUAD) based on metaboli...

    Authors: Zhihao Wang, Kidane Siele Embaye, Qing Yang, Lingzhi Qin, Chao Zhang, Liwei Liu, Xiaoqian Zhan, Fengdi Zhang, Xi Wang and Shenghui Qin

    Citation: Cancer Cell International 2021 21:219

    Content type: Primary research

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  13. Lung adenocarcinoma (LUAD) metastasis significantly reduces patient survival; hence inhibiting the metastatic ability of lung cancer cells will greatly prolong patient survival. Alkaline phosphatase (ALPL), a ...

    Authors: Zhefeng Lou, Weiwei Lin, Huirong Zhao, Xueli Jiao, Cong Wang, He Zhao, Lu Liu, Yu Liu, Qipeng Xie, Xing Huang, Haishan Huang and Lingling Zhao

    Citation: Cancer Cell International 2021 21:217

    Content type: Primary research

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  14. The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active ...

    Authors: Yuting Meng, Xixi Qian, Li Zhao, Nan Li, Shengjie Wu, Baoan Chen, Tong Sun and Xuerong Wang

    Citation: Cancer Cell International 2021 21:216

    Content type: Primary research

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  15. MicroRNAs (miRNAs) are involved in the oncogenesis, development and transformation of lung squamous cell carcinoma (LUSC). miR-665 is clinically significant and acts as a pivotal function in some cancers. Neve...

    Authors: Tian-Jun Chen, Qi Zheng, Fei Gao, Tian Yang, Hui Ren, Yang Li and Ming-Wei Chen

    Citation: Cancer Cell International 2021 21:215

    Content type: Primary research

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  16. Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and renoprotective as wel...

    Authors: Marjan Talebi, Mohsen Talebi, Tahereh Farkhondeh, Jesus Simal-Gandara, Dalia M. Kopustinskiene, Jurga Bernatoniene and Saeed Samarghandian

    Citation: Cancer Cell International 2021 21:214

    Content type: Review

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  18. Epithelial-mesenchymal transition (EMT) has been associated with wound healing, tumorigenesis, and metastasis. Circular RNAs (circRNAs) are functional non-coding RNAs involved in multiple human cancers. Howeve...

    Authors: Guili Xu, Peng Zhang, Hansi Liang, Yunhua Xu, Jian Shen, Wansheng Wang, Mingming Li, Jintao Huang, Caifang Ni, Xueguang Zhang and Xiaoli Zhu

    Citation: Cancer Cell International 2021 21:212

    Content type: Primary research

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  19. Cancers located on the right and left sides of the colon have distinct clinical and molecular characteristics. This study aimed to explore the regulatory mechanisms of location-specific long noncoding RNAs (ln...

    Authors: Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding and Bang-li Hu

    Citation: Cancer Cell International 2021 21:211

    Content type: Primary research

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  20. Emerging evidences have revealed that long non-coding RNAs (lncRNAs) have played critical roles in tumor occurrence and progression. LINC00641 has been reported to be involved in the initiation and development...

    Authors: Jianping Zhang, Shengming Jin, Wenjun Xiao, Xuchao Zhu, Chengyou Jia and Zongming Lin

    Citation: Cancer Cell International 2021 21:210

    Content type: Primary research

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  21. The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished ...

    Authors: Yuhong Guo, Bin Lv, Renfeng Liu, Zhengzai Dai, Feifei Zhang, Yiping Liang, Bo Yu, Duo Zeng, Xiao-Bin Lv and Zhiping Zhang

    Citation: Cancer Cell International 2021 21:209

    Content type: Review

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  22. Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell’s pr...

    Authors: Zahra Farzaneh, Massoud Vosough, Tarun Agarwal and Maryam Farzaneh

    Citation: Cancer Cell International 2021 21:208

    Content type: Review

    Published on:

  24. Cervical cancer is a type of the most common gynecology tumor in women of the whole world. Accumulating data have shown that icariin (ICA), a natural compound, has anti-cancer activity in different cancers, in...

    Authors: Chunyang Li, Shuangqing Yang, Huaqing Ma, Mengjia Ruan, Luyan Fang and Jing Cheng

    Citation: Cancer Cell International 2021 21:206

    Content type: Primary research

    Published on:

  25. Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explor...

    Authors: Siyi Lu, Zhenzhen Liu, Bingyan Wang, Fei Li, Yan Meng, Junwei Wang, Yuxia Wang, Hao Wang, Xin Zhou and Wei Fu

    Citation: Cancer Cell International 2021 21:205

    Content type: Primary research

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  26. Relapse and metastasis in colorectal cancer (CRC) are often attributed to cancer stem-like cells (CSCs), as small sub-population of tumor cells with ability of drug resistance. Accordingly, development of appr...

    Authors: Elmira Gheytanchi, Marzieh Naseri, Feridoun Karimi-Busheri, Fatemeh Atyabi, Ensie Sadat Mirsharif, Mahmood Bozorgmehr, Roya Ghods and Zahra Madjd

    Citation: Cancer Cell International 2021 21:204

    Content type: Primary research

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  27. Long non-coding RNA is considered to be essential to modulate the development and progression of human malignant cancers. And long non-coding RNA can act as crucial modulators by sponging the corresponding mic...

    Authors: Qingyun Pan, Ying Huang, Yirui Wang, Deke Li and Changjiang Lei

    Citation: Cancer Cell International 2021 21:203

    Content type: Primary research

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  28. Microarray profiles of hepatocellular carcinoma (HCC) identified that long intergenic noncoding RNA 00221 (LINC00221) was upregulated. Herein, we aimed to identify the functional significance and underlying me...

    Authors: Lin Yang, Hailong Si, Meng Ma, Yu Fang, Yina Jiang, Jintao Wang, Cheng Zhang and Haijuan Xiao

    Citation: Cancer Cell International 2021 21:202

    Content type: Primary research

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  29. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12935-021-01905-z

    Authors: Hongwang Song, Xiaojun Fu, Chenxing Wu and Shouwei Li

    Citation: Cancer Cell International 2021 21:201

    Content type: Retraction Note

    Published on:

    The original article was published in Cancer Cell International 2020 20:489

  30. VEGF and its receptor family (VEGFR) members have unique signaling transduction system that play significant roles in most pathological processes, such as angiogenesis in tumor growth and metastasis. VEGF-VEGF...

    Authors: Farnaz Khodabakhsh, Parnaz Merikhian, Mohammad Reza Eisavand and Leila Farahmand

    Citation: Cancer Cell International 2021 21:200

    Content type: Review

    Published on:

  31. Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improved, the prognosis of BC patients in advanced stages remains unsatisfac...

    Authors: Dilihumaer Tuluhong, Tao Chen, Jingjie Wang, Huijuan Zeng, Hanjun Li, Wangmu Dunzhu, Qiurong Li and Shaohua Wang

    Citation: Cancer Cell International 2021 21:199

    Content type: Primary research

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  32. Acute myeloid leukaemia (AML) is an aggressive blood cancer. In approximately 30% of the cases, driver mutations in the FLT3 gene are identified. FLT3 inhibitors are used in treatment of such patients together...

    Authors: Jingmei Yang, H. Jonathan G. Lindström and Ran Friedman

    Citation: Cancer Cell International 2021 21:198

    Content type: Primary research

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  33. Osteosarcoma is an aggressive malignant tumor which has attracted worldwide attention. MEX3A may be associated with tumors while has not yet seen its coverage on osteosarcoma. Herein, this study was to investi...

    Authors: Bangmin Wang, Zheping Hong, Chen Zhao, Qing Bi, Junhui Yuan, Jihang Chen and Yi Shen

    Citation: Cancer Cell International 2021 21:197

    Content type: Primary research

    Published on:

  34. High tumor mutation burden (TMB) has gradually become a sensitive biomarker for predicting the response to immunotherapy in many cancers, including lung, bladder and head and neck cancers. However, whether hig...

    Authors: Rong Tang, Xiaomeng Liu, Wei Wang, Jie Hua, Jin Xu, Chen Liang, Qingcai Meng, Jiang Liu, Bo Zhang, Xianjun Yu and Si Shi

    Citation: Cancer Cell International 2021 21:196

    Content type: Primary research

    Published on:

  35. Non-germinal center B-cell-like diffuse large B-cell lymphoma (non-GCB-DLBCL) has worse clinical outcome than GCB-DLBCL, and some relapsed/refractory non-GCB-DLBCL (R/R non-GCB-DLBCL) are even resistant to CD2...

    Authors: Xin Xu, Ting Wei, Weijie Zhong, Rosalind Ang, Ye Lei, Hui Zhang and Qingshan Li

    Citation: Cancer Cell International 2021 21:195

    Content type: Primary research

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  36. Colorectal cancer (CRC) is the third most common cause of cancer globally and the fourth attributable cause of mortality and morbidity due to cancer. An emerging factor contributing to CRC is the gut microbiot...

    Authors: Maryam Ranjbar, Rasoul Salehi, Shaghayegh Haghjooy Javanmard, Laleh Rafiee, Habibollah Faraji, Sima jafarpor, Gordon A. Ferns, Majid Ghayour-Mobarhan, Mostafa Manian and Reza Nedaeinia

    Citation: Cancer Cell International 2021 21:194

    Content type: Review

    Published on:

  37. Osteosarcoma (OS) is the most common primary malignant bone tumor in young people. Tumor-associated macrophages (TAMs) have been reported to play an important role in the development of osteosarcoma. However, ...

    Authors: Hongliang Zhang, Yiyang Yu, Jun Wang, Yu Han, Tingting Ren, Yi Huang, Chenglong Chen, Qingshan Huang, Wei Wang, Jianfang Niu, Jingbing Lou and Wei Guo

    Citation: Cancer Cell International 2021 21:192

    Content type: Primary research

    Published on:

  38. Prostate cancer (PCa) is the most common malignant tumor in developed countries, which has seriously threatened men’s lifestyle and quality of life. The up-regulation of EZH2 is associated with advanced PCa an...

    Authors: Mengyuan Jin, Jiachen Duan, Wei Liu, Jing Ji, Bin Liu and Mingzhi Zhang

    Citation: Cancer Cell International 2021 21:191

    Content type: Primary research

    Published on:

  39. Hepatocellular carcinoma (HCC) ranks the sixth prevalent tumors with high mortality globally. Alternative splicing (AS) drives protein diversity, the imbalance of which might act an important factor in tumorig...

    Authors: Qianhui Xu, Hao Xu, Rongshan Deng, Nanjun Li, Ruiqi Mu, Zhixuan Qi, Yunuo Shen, Zijie Wang, Jingchao Wen, Jiaxin Zhao, Di Weng and Wen Huang

    Citation: Cancer Cell International 2021 21:190

    Content type: Primary research

    Published on:

  40. Cancer is a complex disease orchestrated by various extrinsic and intrinsic pathways. In recent years, there has been a keen interest towards the development of natural extracts-based cancer therapeutics with ...

    Authors: Zeeshan Javed, Haleema Sadia, Muhammad Javed Iqbal, Shazia Shamas, Kausar Malik, Rais Ahmed, Shahid Raza, Monica Butnariu, Natalia Cruz-Martins and Javad Sharifi-Rad

    Citation: Cancer Cell International 2021 21:189

    Content type: Review

    Published on:

  41. Cancers are serious life-threatening diseases which annually are responsible for millions of deaths across the world. Despite many developments in therapeutic approaches for affected individuals, the rate of m...

    Authors: Saeed Mehrzadi, Mohammad Hossein Pourhanifeh, Alireza Mirzaei, Farid Moradian and Azam Hosseinzadeh

    Citation: Cancer Cell International 2021 21:188

    Content type: Review

    Published on:

  42. Myeloma bone disease (MBD) is a severe complication of multiple myeloma (MM) mainly due to an imbalance between enhanced osteoclast activity and reduced osteoblast function. Previous studies have demonstrated ...

    Authors: Zheyu Wu, Yufeng Zhang, Zhiqiang Yang, Yufan Zhu, Yuanlong Xie, Fuling Zhou and Lin Cai

    Citation: Cancer Cell International 2021 21:187

    Content type: Primary research

    Published on:

  43. Early diagnosis of nasopharyngeal carcinoma (NPC) is vital to improve the prognosis of these patients. However, early diagnosis of NPC is typically challenging. Therefore, we explored the pathogenetic roles an...

    Authors: Wei Zheng, Wangzhong Ye, Zijie Wu, Xinyi Huang, Yuanji Xu, Qinyan Chen, Zhizhong Lin, Yanyu Chen, Penggang Bai and Chuanben Chen

    Citation: Cancer Cell International 2021 21:185

    Content type: Primary research

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  44. Cancer dormancy is defined that the residual cancer cells could enter into a state of quiescence and patients remain asymptomatic for years or even decades after anti-tumor therapies. Fibroblasts, which repres...

    Authors: Li Dai, Mao Li, Wei-long Zhang, Ya-Jie Tang, Ya-ling Tang and Xin-hua Liang

    Citation: Cancer Cell International 2021 21:184

    Content type: Review

    Published on:

  45. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jihui Chen, Zhipeng Wang, Shouhong Gao, Kejin Wu, Fang Bai, Qiqiang Zhang, Hongyu Wang, Qin Ye, Fengjing Xu, Hong Sun, Yunshu Lu and Yan Liu

    Citation: Cancer Cell International 2021 21:183

    Content type: Correction

    Published on:

    The original article was published in Cancer Cell International 2021 21:136

  46. Previous studies have found that the microenvironment of cervical cancer (CESC) affects the progression and treatment of this disease. Thus, we constructed a multigene model to assess the survival of patients ...

    Authors: Qian Chen, Bingqing Qiu, Xiaoyun Zeng, Lang Hu, Dongping Huang, Kaihua Chen and Xiaoqiang Qiu

    Citation: Cancer Cell International 2021 21:182

    Content type: Primary research

    Published on:

  47. Lung adenocarcinoma (LUAD) is one of the most common malignancies worldwide. However, the molecular mechanism of LUAD tumorigenesis and development remains unclear. The purpose of this study was to comprehensi...

    Authors: Guoshu Bi, Donglin Zhu, Yunyi Bian, Yiwei Huang, Cheng Zhan, Yong Yang and Qun Wang

    Citation: Cancer Cell International 2021 21:181

    Content type: Primary research

    Published on:

  48. Long noncoding RNAs (lncRNAs) have recently identified as essential gene modulators in numerous cancers. Previous studies have confirmed the oncogenic role of long intergenic nonprotein-coding RNA 00514 (LINC0...

    Authors: Xiao Luo and Hui Wang

    Citation: Cancer Cell International 2021 21:180

    Content type: Primary research

    Published on:

  49. Studies have discussed long noncoding RNA DDX11-AS1 (DDX11-AS1)-mediated downstream mechanism in hepatocellular carcinoma (HCC). The goal of this study was to investigate the regulatory mechanism of DDX11-AS1-...

    Authors: Gangqiang Ding, Yanli Zeng, Dongqiang Yang, Can Zhang, Chongshan Mao, Erhui Xiao, Yi Kang and Jia Shang

    Citation: Cancer Cell International 2021 21:179

    Content type: Primary research

    Published on:

  50. Aberrantly expressed microRNAs play important roles in gastric tumorigenesis. However, use of miRNAs as a therapeutic option in gastric cancer still remains as a challenging problem.

    Authors: Narjes Jafari, Saeid Abediankenari and Hadi Hossein-Nataj

    Citation: Cancer Cell International 2021 21:178

    Content type: Primary research

    Published on:

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Cancer Cell International

ISSN: 1475-2867

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