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Characteristics
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TCGA cohort (n = 29)
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Validation cohort (n = 30)
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P value
|
|---|
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Age (years)
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|
≤ 50
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5 (17.2)
|
7 (23.3)
|
0.561
|
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> 50
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24 (82.8)
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23 (76.7)
|
|
Gender
|
|
Female
|
16 (55.2)
|
10 (33.3)
|
0.091
|
|
Male
|
13 (44.8)
|
20 (66.7)
|
|
Family history
|
|
Yes
|
17 (58.6)
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–
|
–
|
|
No
|
11 (37.9)
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–
|
|
Hepatitis virus
|
|
Yes
|
1 (3.4)
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15 (50.0)
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< 0.001
|
|
No
|
28 (96.6)
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15 (50.0)
|
|
CA19-9
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|
IU/mL
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39.2 (21.5, 223.0)
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16.9 (12.3, 36.5)
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0.008
|
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Pathologic T
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|
T 1
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18 (62.1)
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11 (36.7)
|
0.089
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T 2
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9 (31.0)
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13 (43.4)
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T 3
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2 (6.9)
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2 (6.7)
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T 4
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0
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4 (13.3)
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Pathologic N
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N 0
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22 (75.9)
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15 (50.0)
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0.001
|
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N 1
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3 (10.3)
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15 (50.0)
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N X
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4 (13.8)
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0
|
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Pathologic M
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M 0
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25 (86.2)
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30 (100.0)
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0.052
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M 1/ M X
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4 (13.8)
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0
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Tumor TNM stage
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Stage I
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18 (62.1)
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2 (6.7)
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< 0.001
|
|
Stage II
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8 (27.6)
|
9 (30.0)
|
|
Stage III
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3 (10.3)
|
19 (63.3)
|
|
Stage IV
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0
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0
|
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MVI
|
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Yes
|
4 (13.8)
|
5 (16.7)
|
1.000
|
|
No
|
25 (86.2)
|
25 (83.3)
|
|
ESR1 expression
|
|
Copies
|
5.9 (4.8, 7.0)
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3.4 (2.3, 8.0)
|
0.074
|
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Recurrent status
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Yes
|
17 (58.6)
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17 (56.7)
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1.000
|
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No
|
12 (41.4)
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13 (43.3)
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Survival status
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Alive
|
15 (51.7)
|
16 (53.3)
|
1.000
|
|
Dead
|
14 (48.3)
|
14 (46.7)
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- TNM stage: ACJJ 6TH or 7TH TNM stage; Hepatitis virus: Hepatitis B and/or hepatitis C viruses; MVI: microvascular invasion
